Home Ahead of print Instructions
About us Current issue Subscribe
Editorial board Archives Contact us
Search Submit article Login 
Print this page Email this page
Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 55-59

Association between cognition and peripheral brain-derived neurotrophic factor in a sample of normal adults in Kano, Nigeria

1 Department of Physiology, Neuroscience and Pathophysiology Unit, College of Health Sciences, Bayero University, Zaria, Nigeria
2 Department of Physiotherapy, Aminu Kano Teaching Hospital, Zaria, Nigeria
3 Department of Physiotherapy, Bayero University, Zaria, Nigeria
4 Department of Community Medicine, Bayero University and Aminu Kano Teaching Hospital, Zaria, Nigeria
5 Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria

Correspondence Address:
Dr. Isyaku U Yarube
Department of Physiology, Neuroscience and Pathophysiology Unit, College of Health Sciences, Bayero University, Kano
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njbcs.njbcs_46_17

Rights and Permissions

Introduction: Cognition is an important physiological and social element for both humans and animals. There is paucity of literature on cognitive function in Africans. Furthermore, the molecular mechanisms involved in cognition have not been fully elucidated. Brain-derived neurotrophic factor (BDNF) has a role in neuronal plasticity and cognition. However, the relationship between cognitive performance and serum BDNF levels has not been demonstrated in an African population. This study aimed to assess cognition and BDNF level and determine their relationship in a population of healthy adult Africans. Materials and Methods: Cognitive function and BDNF were determined using Mini Mental State Examination and enzyme-linked immunosorbent assay kit, respectively. SPSS statistics was used to process data. Results: Thirty male and female volunteers with a mean age of 48.7 ± 11.32 years were studied. The median cognitive score was 24.00 (21 and 28) with no sex variation (U = 107, P = 0.833). The median value of serum BDNF concentration was 2.09 ± 0.15 ng/L and statistically the same in males and females (t = 1.276, P = 0.213). Cognitive score correlated moderately with BDNF level (r = 0.369, P = 0.045), but not with sociodemographic or anthropometric characteristics. Conclusion and Recommendation: It was concluded that the population studied had normal cognitive function, which was not affected by sociodemographic and anthropometric characteristics. BDNF was a mediator of global cognitive function and was positively associated with registration and negatively associated with language domains of cognition. Peripheral levels of BDNF may potentially serve as a biomarker and index of cognitive evaluation in clinical settings.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded172    
    Comments [Add]    
    Cited by others 1    

Recommend this journal