Home Ahead of print Instructions
About us Current issue Subscribe
Editorial board Archives Contact us
Search Submit article Login 
Print this page Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 2  |  Page : 109-113

High hemolytic markers in G6PD-deficient compared to G6PD-normal male leprosy patients


Department of Haematology, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria

Correspondence Address:
Dr. Ibrahim Musa Idris
Department of Haematology, Aminu Kano Teaching Hospital, PMB 3452, Kano
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njbcs.njbcs_29_18

Rights and Permissions

Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency (Gd) is the most common enzymopathy, which is inherited as an X-linked recessive disorder. Individuals with Gd are prone to hemolysis upon exposure to oxidant stress. Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Both leprosy and Gd are common in Nigeria, and treatment of leprosy with dapsone can precipitate hemolysis in Gd. Aims: The aims of this study were to determine the prevalence of Gd, and compare the hematological and biochemical indices of Gd with G6PD-replete (Gd+) male leprosy patients in Kano, Nigeria. Settings and Design: This was a cross-sectional study. A total of 198 male participants with leprosy were recruited at the Yadakunya leprosarium in Kano, Nigeria. Materials and Methods: Relevant data were obtained through questionnaires and case notes review. Venous blood was collected for analysis. Statistical Analysis: Unpaired t test and Chi square test were used for comparison of variables. Results: The prevalence of G6PD deficiency was 9% in male leprosy patients. Mean Hb of Gd(10.56 ± 2.82 g/dl) was lower than Gd+(12.9 ± 2.31 g/dl), P value < 0.001. Platelet (293.52 × ±3.19 × 109/l vs. 176.31 ± 2.83 × 109/l; P value < 0.001), reticulocytes (4.49 ± 2.72% vs. 2.01 ± 1.07%, P value < 0.001), bilirubin [1.04 ± 0.22 mg/dl vs. 0.46 ± 0.27 mg/dl; P value < 0.001], and lactate dehydrogenase (LDH) [269.82 ± 58.54 mg/dl vs. 130.26 ± 51.83 mg/dl; P value <0.001] were higher in Gd than Gd+. Conclusion: Lower Hb and higher hemolytic markers in Gd indicate ongoing hemolysis, which can be precipitated by dapsone.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed118    
    Printed4    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    

Recommend this journal