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Year : 2019  |  Volume : 16  |  Issue : 2  |  Page : 109-113

High hemolytic markers in G6PD-deficient compared to G6PD-normal male leprosy patients

Department of Haematology, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria

Correspondence Address:
Dr. Ibrahim Musa Idris
Department of Haematology, Aminu Kano Teaching Hospital, PMB 3452, Kano
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njbcs.njbcs_29_18

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Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency (Gd) is the most common enzymopathy, which is inherited as an X-linked recessive disorder. Individuals with Gd are prone to hemolysis upon exposure to oxidant stress. Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Both leprosy and Gd are common in Nigeria, and treatment of leprosy with dapsone can precipitate hemolysis in Gd. Aims: The aims of this study were to determine the prevalence of Gd, and compare the hematological and biochemical indices of Gd with G6PD-replete (Gd+) male leprosy patients in Kano, Nigeria. Settings and Design: This was a cross-sectional study. A total of 198 male participants with leprosy were recruited at the Yadakunya leprosarium in Kano, Nigeria. Materials and Methods: Relevant data were obtained through questionnaires and case notes review. Venous blood was collected for analysis. Statistical Analysis: Unpaired t test and Chi square test were used for comparison of variables. Results: The prevalence of G6PD deficiency was 9% in male leprosy patients. Mean Hb of Gd(10.56 ± 2.82 g/dl) was lower than Gd+(12.9 ± 2.31 g/dl), P value < 0.001. Platelet (293.52 × ±3.19 × 109/l vs. 176.31 ± 2.83 × 109/l; P value < 0.001), reticulocytes (4.49 ± 2.72% vs. 2.01 ± 1.07%, P value < 0.001), bilirubin [1.04 ± 0.22 mg/dl vs. 0.46 ± 0.27 mg/dl; P value < 0.001], and lactate dehydrogenase (LDH) [269.82 ± 58.54 mg/dl vs. 130.26 ± 51.83 mg/dl; P value <0.001] were higher in Gd than Gd+. Conclusion: Lower Hb and higher hemolytic markers in Gd indicate ongoing hemolysis, which can be precipitated by dapsone.

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