Home Ahead of print Instructions
About us Current issue Subscribe
Editorial board Archives Contact us
Search Submit article Login 
Print this page Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 51-54

Association of ABO neo-maternal incompatibility and neonatal jaundice in Nguru, Nigeria


1 Department of Haematology, Federal Medical Centre, Nguru, Yobe State, Nigeria
2 Department of Haematology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
3 Department of Haematology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
4 Department of Paediatrics, Federal Medical Centre, Nguru, Yobe State, Nigeria

Correspondence Address:
Dr. Hadiza Tikau Idi
Department of Haematology, Federal Medical Centre, Nguru, Yobe State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njbcs.njbcs_28_18

Rights and Permissions

Context: ABO blood group antigens are inherited and specific to an individual. In pregnancy, active immunisation occurs when the foetus is of a different ABO blood group from the mother and may result in neonatal jaundice (NNJ). Therefore, monitoring and evaluation of mothers at booking and throughout pregnancy and the postpartum period is important in management. Aim: The aim of this study is to determine the prevalence of neo-maternal ABO blood group incompatibility and to assess any relationship with NNJ among mother-neonate pairs in Nguru, Northeast Nigeria. Subjects and Methods: This was a cross-sectional descriptive study of 200 pregnant women at Federal Medical Centre, Nguru, Yobe State, Nigeria in 2015. ABO blood group antigens of both mothers and neonates were determined while direct Coomb's test (DCT), full blood counts, reticulocyte counts and bilirubin assays were determined for neonates of ABO-incompatible neo-maternal pairs. Data were analysed using SPSS Version 20, and a P ≤ 0.05 was considered as statistically significant. Results: The mean age of the mothers was 26.4 ± 6.2 years. Blood group O had the highest frequencies among mothers and neonates 58% and 57.5%, respectively. Although 28% of the mother-neonate pairs were ABO blood group incompatible, only 12.5% of the incompatible neonates had a positive cord blood DCT, and only 6% of the neonates developed jaundice. There was a strong and positive association between ABO neo-maternal blood group incompatibility and NNJ P = 0.007 (Fishers' exact test), odds ratio = 8.52, 95% confidence interval; 1.665, 43.591. Conclusion: ABO neo-maternal incompatibility is common, and it has a strong positive association with NNJ. There is a need for routine neonatal ABO screening, especially where jaundice exists.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed277    
    Printed14    
    Emailed0    
    PDF Downloaded24    
    Comments [Add]    

Recommend this journal